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Y1 - 2018/6. N2 - Objective: The monoaminergic stabiliser (−)-OSU6162 has in previous studies shown promising effects on mental fatigue after stroke and traumatic brain injury. This study investigated the safety and effectiveness of (−)-OSU6162 in patients with myalgic encephalomyelitis/chronic fatigue Maria Carlsson's 93 research works with 6,361 citations and 5,204 reads, including: Open-label study with the monoamine stabilizer (-)-OSU6162 in myalgic encephalomyelitis/chronic fatigue syndrome The rights to OSU6162 are held by Nobel Prize laureate Arvid Carlsson, who together with his team in Gothenburg has developed the compound. He is also one of the study's co-authors.

Rung JP(1), Carlsson A, Markinhuhta KR, Carlsson ML. Author information: (1)The Arvid Carlsson Institute for Neuroscience, Institute of Clinical Neuroscience, The Sahlgrenska Academy, Göteborg University, Medicinaregatan 11, SE-405 30 Göteborg, Sweden. johan.rung@psychiat.gu.se 2017-09-12 2015-03-19 Arvid Carlsson | Institutionen för neurovetenskap och fysiologi. Maria L. Carlsson -OSU6162 (OSU6162) and ACR16 are two structurally related compounds ascribed such properties, principally because of their stabilizing effects on motor activity in rodents. 2015-07-22 ARVID AND LENA CARLSSON'S COLUMNS Latest news: New substance against brain fatigue and narcolepsy The substance OSU6162 was developed by Nobel laureate Arvid Carlsson. According to clinical trials which were initiated in 2010, OSU6162 seems to alleviate dramatically the symptoms of brain fatigue after stroke.

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2010 — Moderators: Arvid Carlsson (Gothenburg) & Hans- Ingvar Karlsson (Gothenburg) The Dopamine Stabilizer (-)-OSU6162 Selectively. av CG Gottfries · 2016 · Citerat av 1 — OSU6162. OSU6162 är en substans som togs fram i början av 90-talet av professor.

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92 år gammal är han fortfarande aktiv forskare – just nu arbetar han vidare med en molekyl som han och hans kollegor tog fram redan under 80-talet. Arvid Carlsson, who was awarded the Nobel Prize for Medicine in 2000 for showing that dopamine is a neurotransmitter, was interviewed in 2013 by Antonia Rubinstein about the use of apomorphine to treat alcoholism.

2012-11-15 · The monoamine stabilizer (-)-OSU6162 [(S)-(-)-3-(3-methanesulfonyl-phenyl)-1-propyl-piperidine] (or PNU-96391) was generously provided to Arvid Carlsson by Pfizer Pharmaceuticals. The OSU6162 doses (15 and 30 mg/kg subcutaneously [SC]) were chosen on the basis of previous studies showing that this dose range induces high striatal D2 receptor occupancy without inducing catalepsy in rats ( 20 ). Professor Carlsson showed that dopamine acts as a messenger molecule in the brain and that a lack of this substance causes impaired motor skills, such as in Parkinson's disease. 92 year old Arvid Carlsson is still an active researcher – right now he is working on OSU6162, a molecule dates back to the 80's. Arvid Carlsson discovered a neurotransmitter called dopamine in the brain and described its role in our ability to move. -OSU6162 in treatment of myalgic encephalomyelitis/chronic fatigue OSU6162 är ett läkemedel som framtagits av professor Arvid Carlsson.
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Monoaminergic pathways in brain. From Fuxe and Andén (1966). CHLORPROMAZINE ¿ÿ€;receptor££ fbrgetlce// mitochoñ

Arvid Carlsson's 409 research works with 28,027 citations and 5,811 reads, including: A randomised controlled trial of the monoaminergic stabiliser (−)-OSU6162 in treatment of myalgic 2014-06-09 · OSU6162, som den nya substansen heter, beskrivs som ett 'smart' läkemedel. Arvid Carlsson och hans kollegor har utvecklat det utifrån bland andra kroppens egna dopamin-och serotonin molekyler. Sedan har Arvid Carlsson, som han säger, 'snickrat på det' så att det ska (−)-OSU6162 is a dopamine stabilizer that can counteract both hyperdopaminergic and hypodopaminergic states. In this study, D2/D3 receptor occupancy of (−)-OSU6162 in the human brain was The locomotor effects of (−)- and (+)-OSU6162 were evaluated in ‘low activity’ animals (reserpinized mice and habituated rats) and ‘high activity’ animals (drug-naive mice and non-habituated rats). Both enantiomers of OSU6162 had dual effects on behavior, stimulating locomotor activity in ‘low activity’ animals and inhibiting locomotor activity in ‘high activity’ animals Arvid Carlsson önskar förhandla med Pharmacia om att ta över OSU6162 för att kunna utveckla båda substanserna. Den mest lovande indikationen för dopaminstabiliserarna, förutom biverkningar av L-dopa och Huntingtons sjukdom, är schizofreni. För Arvid Carlsson är forskning som missbruk.
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1 dec. 2014 — 'OSU6162' och där står det pyttelite men intressant information om en medicin som är framställd av en professor som heter Arvid Carlsson. dopaminstabilisatorn OSU6162 vid ME/CFS (i samarbete med Arvid Carlsson Research AB) Immunstörning vid ME/CFS m fl forskare Hypotes: ME/CFS The dopamine stabilizer (–)– OSU6162 – a potential novel treatment for alcohol Pia Steensland, Ida Fredriksson, Sarah Holst, Johan Franck, Arvid Carlsson. Carlsson, Arvid, Nilsson, Marie, Carlsson, Maria L., Schuit, R. C. och Gottfries, Carl-Gerhard, Open-label study with the monoamine stabilizer (-)-OSU6162 in Nilsson, Marie, Carlsson, Maria L., Carlsson, Arvid, Wahlström, Jan och Haghighi, Sara, Tolerability and efficacy of the monoaminergic stabilizer (-)-OSU6162 13 juli 2014 — Fipemazole • Alfa 2 adrenerg receptor antagonist • Under utveckling mot ofrivilliga rörelser • OSU 6162 – Arvid Carlsson • dopaminstabilisator.

Arvid Carlsson and Kjell Svensson are inventors of OSU6162.
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Molekylen utvecklades tillsammans med ett läkemedelsföretag. År 2006 gick substanspreparatet tillbaka till Arvid Carlsson. (-)-OSU6162 offers promise for the treatment of HD, as a drug with good tolerability, capable of improving the patients' experienced non-motor functions such as energy and mood and thus alleviating symptoms of great importance for their quality of life. We received (−)-OSU6162 from Drs. Arvid Carlsson and Pia Steensland (Karolinska Institutet) and dissolved it in saline (5 mL/kg).